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KMID : 0927720100110030229
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Korean Clinical Diabetes
2010 Volume.11 No. 3 p.229 ~ p.238
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Effects of Calpain-10 and Adiponectin Gene Polymorphisms on Insulin Secretion and Resistance in Patients with Type 2 Diabetes Mellitus
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Han Jeong-Woo
Shim Woo-Ho
Lee Eun-Hae
Lee Young-Mi
Kim Min-goo
Kim Soon-Ae
Beom Sun-Hee
Kim Eun-Sook
Yoo Jeong-Seon
Nam Ji-Sun
Cho Min-Ho
Park Jong-Suk
Ahn Chul-Woo
Kim Kyung-Rae
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Abstract
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Background: Genetic variations in the calpain-10 and adiponectin genes affect insulin secretion in patients with type 2 diabetes mellitus (T2DM). Recently, several single nucleotide polymorphisms (SNPs) in the adiponectin and calpain-10 genes have been reported to be associated with T2DM and components of insulin resistance and secretion. The aim of this study was to determine whether there is an association between specific CAPN10, the adiponectin gene and T2DM in the Korean population.
Methods: A total of 249 Korean T2DM subjects and 131 non-diabetic subjects were enrolled in this study. G276T and T45G frequencies of the adiponectin gene were examined in all subjects. All subjects were genotyped for CAPN10 SNP-43 and -63. The clinical characteristics and genetic levels of the subjects were compared between genotypes.
Results: Variations in CAPN10 SNP -63 T/T were more highly associated in T2DM patients than in normal controls. The results of this study suggest that the single SNP-63 predicts susceptibility to T2DM. However, calpain 10, SNP-43, adiponectin T45G and intron G276T genetic frequencies are not associated with T2DM.
Conclusions: Variations in CAPN10 SNP-63 play a role in susceptibility to T2DM. SNP-43 and adiponectin SNP-45 and -276 are not associated with glucose tolerance.
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KEYWORD
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Adiponectin, Calpain-10, Type 2 diabetes mellitus
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